反应详情

温度

100 °C

10 g of 3-aminophenoxyacetic acid methylester are solved in 19 g benzyl chloride. Subsequently, 14 g of sodium carbonate are added portionwise and the temperature is raised to 100° C. The reaction mixture is stirred at this temperature for 3 hours. The insoluble salt is filtered off and washed with 100 ml of ethyl acetate. The combined filtrates are kept at 5° C. for 12 h. After the extraction with water and brine, the organic phase is dried with sodium sulfate and the solvent is removed in vacuum (50° C., 10−2 mbar). Yield: 22 g (dark oil).

1. filtrationThe insoluble salt is filtered off
2. washwashed with 100 ml of ethyl acetate
3. waitThe combined filtrates are kept at 5° C. for 12 h
4. extractionAfter the extraction with water and brine
5. dry with materialthe organic phase is dried with sodium sulfate
6. customthe solvent is removed in vacuum (50° C., 10−2 mbar)