2,6-Di-tert-butyl-4-methylphenol → HCID 59348346, compound

HRID 414891Notes

Reaction equation

HRID 414891 reaction equation
C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O.C([O-])(=O)C.[Na+].CC1C=C(C(C)(C)C)C(O)=C(C(C)(C)C)C=1.[CH3:33][CH:34]([O:41][CH2:42][CH2:43][CH2:44][CH2:45][OH:46])[CH2:35][CH2:36][CH2:37][CH:38]([CH3:40])[CH3:39]>ClCCl>[CH3:33][CH:34]([O:41][CH2:42][CH2:43][CH2:44][CH:45]=[O:46])[CH2:35][CH2:36][CH2:37][CH:38]([CH3:39])[CH3:40]

Participants

6

Reactant 4

HCID 314042,6-Di-tert-butyl-4-methylphenolHCID 517045Sodium AcetateHCID 86642020HCID 86642020, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 59348346HCID 59348346, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 250 mL 3-necked flask was equipped with a thermocouple pocket, magnetic stirrer and condenser. PCC (13.9 g, 0.64 mols), sodium acetate (1.22 g, 0.015 mol), stavox (0.01 g) and dichloromethane (100 mL) were added to the flask. 4-[(1,5-dimethylhexyl)oxy]butan-1-ol (10.0 g, 0.05 mol) was added over 5 minutes with stirring. The reaction was stirred for 3 hrs at room temperature. After this time the reaction mixture contained ca. 82% of the desired product (RPA GC).

Workup

  1. customA 250 mL 3-necked flask was equipped with a thermocouple pocket, magnetic stirrer and condenser
  2. stirringThe reaction was stirred for 3 hrs at room temperature

Sources & evidence

ORD record
ord-98e5de63fd55448591c83c53e2f1b3c7
Source dataset
uspto-grants-2012_01
Patent number
US08088725B2

Reaction notes

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