HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → (S)-Methyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Boc-L-Lys(Z)-OMe | HCID 11132998 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-Methyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate | HCID 7018772 | — |
Reaction Steps
1.0 g of Boc-Lys(Cbz)-OMe (5) was dissolved in 40 mL MeOH:Ethyl acetate. 100 mg of Palladium on active carbon (Pd/C) was added to the solution. The solution was stirred under hydrogen for 2 hrs. The organic solution was filtered through Celite and washed with 10 mL MeOH. The filtrate was evaporated under reduced pressure to yield Boc-Lys-OMe of formula (6)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088757B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-0a66b2c927b04473a72ca051f029c794 |
| Source note | uspto-grants-2012_01 |