Sodium borohydride → HCID 44233541, compound

HRID 414915Notes

Reaction equation

HRID 414915 reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[O:22][C:21]([CH:23]=[O:24])=[CH:20][CH:19]=4)=[CH:14][N:13]3[CH:25]=2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[O:22][C:21]([CH2:23][OH:24])=[CH:20][CH:19]=4)=[CH:14][N:13]3[CH:25]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86651941HCID 86651941, compound

Product 1

HCID 44233541HCID 44233541, compoundYield 37.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

122 mg of sodium borohydride are added, in small portions, to 104 mg of 5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours, and the solvent is then evaporated off under reduced pressure. The residue is taken up between dichloromethane and water. The organic phase is separated, dried over sodium sulphate and concentrated under reduced pressure. 39 mg of compound are obtained.

Workup

  1. customthe solvent is then evaporated off under reduced pressure
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-168cdef8280448c485a0f1aa1909b388
Source dataset
uspto-grants-2012_01
Patent number
US08088765B2

Reaction notes

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