HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-Methoxy-N-methyl-1H-indazole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Indazole-3-carboxylic acid | HCID 78250 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-Methoxy-N-methyl-1H-indazole-3-carboxamide | HCID 16036867 | 69.1% |
Reaction Steps
In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088765B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-9738909b5b2b4a118505adb3bac6ad7f |
| Source note | uspto-grants-2012_01 |