4-Piperidineethanol → HCID 135994988, compound

HRID 414960Notes

Reaction equation

HRID 414960 reaction equation
[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][C:5]1[NH:6][C:7](=[O:15])[C:8]([C:13]#[N:14])=[C:9](SC)[N:10]=1.[NH:20]1[CH2:25][CH2:24][CH:23]([CH2:26][CH2:27][OH:28])[CH2:22][CH2:21]1>C(#N)C>[OH:28][CH2:27][CH2:26][CH:23]1[CH2:24][CH2:25][N:20]([C:9]2[N:10]=[C:5]([CH2:4][C:3]3[CH:16]=[CH:17][CH:18]=[CH:19][C:2]=3[CH3:1])[NH:6][C:7](=[O:15])[C:8]=2[C:13]#[N:14])[CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 739534-PiperidineethanolHCID 58407904HCID 58407904, compound

Product 1

HCID 135994988HCID 135994988, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.1 g (0.37 mmol) of 2-(2-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile is heated with 0.14 g (1.1 mmol) of 2-(4-piperidinyl)ethan-1-ol in 3 ml of acetonitrile at 90° C. under argon for five days. After cooling to room temperature, the crude product is purified by preparative HPLC. 13 mg (10% of theory) of the title compound are obtained as a colourless solid.

Workup

  1. customthe crude product is purified by preparative HPLC

Sources & evidence

ORD record
ord-1b8a027b0d874789871fa3094d6d385d
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

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