HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Dimethylpiperidine → 4-(4,4-Dimethylpiperidin-1-yl)-2-(3-chlorobenzyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Dimethylpiperidine | HCID 138100 | — |
| Reactant | 2-(3-Chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 58407802 | — |
| Product | 4-(4,4-Dimethylpiperidin-1-yl)-2-(3-chlorobenzyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 135995032 | — |
Reaction Steps
In analogy to the preparation of Example 1, 150 mg (0.51 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 582 mg (5.14 mmol) of 4,4-dimethylpiperidine to give 96 mg (52% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088769B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-3a2af563e55642549d5e7367ca025bfe |
| Source note | uspto-grants-2012_01 |