HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 2-(3-Chlorobenzyl)-4-[(2-methoxyethyl)amino]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 2-(3-Chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 58407802 | — |
| Product | 2-(3-Chlorobenzyl)-4-[(2-methoxyethyl)amino]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 135995126 | — |
Reaction Steps
In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 257 mg (3.43 mmol) of 2-methoxyethylamine to give 61 mg (56% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088769B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-6f1c8c7822014db5a8d99688561bc42a |
| Source note | uspto-grants-2012_01 |