HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylpiperidine → 4-(4-Methylpiperidin-1-yl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylpiperidine | HCID 69381 | — |
| Reactant | 4-(Methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile | HCID 58407942 | — |
| Product | 4-(4-Methylpiperidin-1-yl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile | HCID 135510738 | — |
Reaction Steps
In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 377 mg (3.80 mmol) of 4-methylpiperidine to give 65 mg (54% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088769B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-b2b513cb14f142e18044211b149a900f |
| Source note | uspto-grants-2012_01 |