HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Dimethylpiperidine → 4-(4,4-Dimethylpiperidin-1-yl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Dimethylpiperidine | HCID 138100 | — |
| Reactant | 4-(Methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile | HCID 58407942 | — |
| Product | 4-(4,4-Dimethylpiperidin-1-yl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile | HCID 135995053 | — |
Reaction Steps
In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 430 mg (3.80 mmol) of 4,4-dimethylpiperidine to give 42 mg (34% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088769B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-70558a5718784a1f8ac920042e608df0 |
| Source note | uspto-grants-2012_01 |