4-Piperidineethanol → HCID 135995070, compound

HRID 414984Notes

Reaction equation

HRID 414984 reaction equation
CS[C:3]1[N:4]=[C:5]([CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[NH:6][C:7](=[O:11])[C:8]=1[C:9]#[N:10].[NH:18]1[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25][OH:26])[CH2:20][CH2:19]1>>[OH:26][CH2:25][CH2:24][CH:21]1[CH2:22][CH2:23][N:18]([C:3]2[N:4]=[C:5]([CH2:12][C:13]3[CH:17]=[CH:16][S:15][CH:14]=3)[NH:6][C:7](=[O:11])[C:8]=2[C:9]#[N:10])[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 739534-PiperidineethanolHCID 584079424-(Methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

Product 1

HCID 135995070HCID 135995070, compound

Procedure

In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 491 mg (3.80 mmol) of 2-(4-piperidinyl)ethan-1-ol to give 64 mg (49% of theory) of the title compound.

Sources & evidence

ORD record
ord-ef32d7ea069f44a59f4fa398dbe79a48
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

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