1,4-Dioxa-8-azaspiro(4.5)decane → HCID 135994983, compound

HRID 414986Notes

Reaction equation

HRID 414986 reaction equation
CS[C:3]1[N:4]=[C:5]([CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[NH:6][C:7](=[O:11])[C:8]=1[C:9]#[N:10].[O:18]1[C:22]2([CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[O:21][CH2:20][CH2:19]1>>[O:18]1[C:22]2([CH2:27][CH2:26][N:25]([C:3]3[N:4]=[C:5]([CH2:12][C:13]4[CH:17]=[CH:16][S:15][CH:14]=4)[NH:6][C:7](=[O:11])[C:8]=3[C:9]#[N:10])[CH2:24][CH2:23]2)[O:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 584079424-(Methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

Product 1

HCID 135994983HCID 135994983, compound

Procedure

In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 544 mg (3.80 mmol) of 1,4-dioxa-8-azaspiro[4.5]decane to give 65 mg (48% of theory) of the title compound.

Sources & evidence

ORD record
ord-9c57e779e9bf4c1695c2fadf1fb782c8
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

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