4-Piperidineethanol → HCID 135477786, compound

HRID 414992Notes

Reaction equation

HRID 414992 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:26]=[CH:25][CH:24]=[CH:23][C:10]=2[CH2:11][C:12]2[NH:13][C:14](=[O:22])[C:15]([C:20]#[N:21])=[C:16](SC)[N:17]=2)=[CH:5][CH:4]=1.[NH:27]1[CH2:32][CH2:31][CH:30]([CH2:33][CH2:34][OH:35])[CH2:29][CH2:28]1>>[OH:35][CH2:34][CH2:33][CH:30]1[CH2:31][CH2:32][N:27]([C:16]2[N:17]=[C:12]([CH2:11][C:10]3[CH:23]=[CH:24][CH:25]=[CH:26][C:9]=3[C:6]3[CH:7]=[N:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[NH:13][C:14](=[O:22])[C:15]=2[C:20]#[N:21])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 739534-PiperidineethanolHCID 16049991HCID 16049991, compound

Product 1

HCID 135477786HCID 135477786, compound

Procedure

In analogy to the preparation of Example 1, 80 mg (0.22 mmol) of 2-[2-(6-methoxypyridin-3-yl)-benzyl]-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 85 mg (0.65 mmol) of 2-(4-piperidinyl)ethan-1-ol to give 62 mg (63% of theory) of the title compound.

Sources & evidence

ORD record
ord-6db699eb0e274fa7857173a0366566bb
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

Loading…