HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 414996Generated: October 30, 2026
Benzoic acid, 2-amino-5-iodo- → 6-Iodoquinazolin-4-one
https://huagongshe.com/reaction/414996
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| Reactant | Formamidine acetate | HCID 160693 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Iodoquinazolin-4-one | HCID 135401666 | 81% |
Reaction Steps
A solution of 2-amino-5-iodobenzoic acid (14.2 g, 50 mmol) and formamidine acetate (6.75 g, 65 mmol) in ethanol (200 mL) was refluxed for 20 hours. After cooling to 0° C. the solid product was collected by filtration. Further drying in a vacuum provided 6-Iodo-4-quinazolinone (11 g, 81%) as a gray solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088766B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-4dd56ed35fff4431af63ae26e9f4037f |
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| Source note | uspto-grants-2012_01 |
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