HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 4-Quinazolinamine,6-iodo-n-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]-,hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 4-Chloro-6-iodoquinazoline | HCID 11173809 | — |
| Reactant | 3-Methyl-4-((6-methylpyridin-3-yl)oxy)aniline | HCID 11424434 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 4-Quinazolinamine,6-iodo-n-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]-,hydrochloride | HCID 66623307 | 76% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A mixture of 3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamine (4.96 g, 23.18 mmol), 4-Chloro-6-iodo-quinazoline 604 g, 22.06 mmol) in tBuOH (60 mL) and DCE (60 mL) was refluxed for 6 hours. The reaction was cooled to 0° C. and the solid product (8.44 g, 76%) was isolated by filtration and washed with cold CH2Cl2 (50 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088766B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-9892228857a047a982fb3083ebe4fefa |
| Source note | uspto-grants-2012_01 |