Acetic Anhydride → HCID 178486873, compound

HRID 415017Notes

Reaction equation

HRID 415017 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([OH:13])=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[OH:14].[CH3:15][C:16](OC(C)=O)=[O:17]>N1C=CC=CC=1>[OH:13][C:7]1[C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[C:4]([O:14][C:16](=[O:17])[CH3:15])[CH:5]=2)[N:10]=[CH:9][N:8]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178486868HCID 178486868, compound

Product 1

HCID 178486873HCID 178486873, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 7-Methoxy-quinazoline-4,6-diol (6.2 g, 32.3 mmol), Ac2O (100 mL) and pyridine (10 mL) was heat to 100° C., and stirred for 3 hours. The reaction was then cooled to room temperature and poured to ice water (300 mL). The product was isolated by filtration, washed with water (200 mL) and dried to give 7.61 g (32.4 mmol, 100%) of desired product.

Workup

  1. temperatureThe reaction was then cooled to room temperature
  2. customThe product was isolated by filtration
  3. washwashed with water (200 mL)
  4. customdried

Sources & evidence

ORD record
ord-ef03563a05fd4561bca314f0573b0d09
Source dataset
uspto-grants-2012_01
Patent number
US08088766B2

Reaction notes

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