HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415023Generated: October 30, 2026
1,2-Dichloroethane → [1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-(6-iodo-quinazolin-4-yl)-amine hydrochloride
https://huagongshe.com/reaction/415023
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 1-(3-Fluorobenzyl)-1H-indazol-5-amine | HCID 7147073 | — |
| Reactant | 4-Chloro-6-iodoquinazoline | HCID 11173809 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | [1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-(6-iodo-quinazolin-4-yl)-amine hydrochloride | HCID 66623800 | — |
Reaction Steps
Follow general procedure from Example 1, step E. 4-chloro-6-iodoquinazoline (1.18 g, 4.06 mmol) is mixed with 1-(3-Fluoro-benzyl)-1H-indazol-5-ylamine (1.09 g, 4.52 mmol), and a mixture of DCE (10 ml) and t-BuOH (10 ml) is added. The mixture is heated at 90° C. (oil bath temperature) for 8 hours. At 5 hours of heating LC/MS reveals substantial amount of product. Yield is 1.35 g (56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088766B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-ac013447405c4ca0bfa56735ec193f04 |
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| Source note | uspto-grants-2012_01 |
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