Hydrochloric Acid → HCID 66623234, compound

Participants

Reaction Steps

To a Parr hydrogenation bottle was added 13.0 g of 2-(3,4-dinitrophenoxy)acetate, Raney Nickel (2.0 g, wet), THF (100 mL) and EtOH (150 mL). The atmosphere of the vessel was replaced by hydrogen gas. The reaction was shaken on a Parr hydrogenator at 40 psi at room temperature, overnight. The catalyst was filtered through a plug of Celite and the filtrate was concentrated under reduced pressure to give a residue, which was dissolved in methanol, acidified with 4 N hydrogen chloride in 1,4-dioxane and filtered. The resulting filtrate was concentrated under reduced pressure to give ethyl 2-(3,4-diaminophenoxy)acetate dihydrochloride (8.5 g, 83%), and was used directly in the next step without any further purification. MS (EI): 276 (MH+).

Provenance & Evidence