Hydrochloric Acid → HCID 178522486, compound

Participants

Reaction Steps

1-dimethylethyl 4-({4-[({4-[(1H-benzimidazol-2-ylamino)carbonyl]-1H-imidazol-5-yl}carbonyl)amino]-3-chlorophenyl}oxy)piperidine-1-carboxylate was treated with 4M hydrogen chloride in dioxane to give N4-1H-benzimidazol-2-yl-N5-[2-chloro-4-(piperidin-4-yloxy)phenyl]-1H-imidazole-4,5-dicarboxamide as its hydrochloride salt in 83% yield. 1H-NMR (400 MHz, DMSO-d6): 13.9 (s, br, 1H), 13.7 (s, 1H), 12.2 (s, 1H), 10.4 (s, 1H), 8.41-8.39 (m, 1H), 8.15 (s, 1H), 8.01 (s, 1H), 7.45 (s, 2H), 7.07 (s, 2H). MS (EI): 450 (MH+).

Provenance & Evidence