Dimethylformamide → HCID 59349586, compound

Participants

Reaction Steps

A 100 mL flask was charged with 2-fluoro-3-nitroaniline (19.108 mmol, commercially available from Aldrich), DMF (50 mL), HATU (26.05 mmol) and DIEA (52.11 mmol) and stirred at room temperature over night. The reaction mixture was diluted with ethyl acetate and washed with 10% lithium chloride solution (3×), 2 M sodium chloride (3×), dried over anhydrous sodium sulfate, filtered and the solvent was removed using the rotary evaporator under reduced pressure to yield N-(2-fluoro-3-nitrophenyl)-1-methylpiperidine-3-carboxamide which was used in the next step without further purification. MS (EI): 282 (MH+).

Provenance & Evidence