Hydrochloric Acid → HCID 178479721, compound

Participants

Reaction Steps

A flask was charged with tert-butyl 4-(4-(4-(1H-benzo[d]imidazol-2-ylcarbamoyl)-1H-imidazole-5-carboxamido)-2-chlorophenoxy)piperidine-1-carboxylate (260 mg, 0.45 mmol), 4 N hydrogen chloride in 1,4-dioxane (1 mL, 4 mmol) and 1,4-dioxane (50 mL), and the reaction mixture was stirred for 15 hours at room temperature. The resulting solid was filtered off and air dried to give 0.228 g of N4-(1H-benzo[d]imidazol-2-yl)-N5-(2-chloro-4-(piperidin-4-yloxy)phenyl)-1H-imidazole-4,5-dicarboxamide hydrochloride (99% yield). 1H-NMR (400 MHz, DMSO-d6): δ 13.9 (s, br, 1H), 13.7 (s, 1H), 12.2 (s, 1H), 10.4 (s, 1H), 8.41-8.39 (m, 1H), 8.15 (s, 1H), 8.01 (s, 1H), 7.45 (s, 2H), 7.07 (s, 2H). MS (EI): 450 (MH+).

Provenance & Evidence