Hydrochloric Acid → HCID 178423584, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl 4-(2-{[(4-{[(5-bromo-2-methylphenyl)amino]carbonyl}-1H-imidazol-5-yl)carbonyl]amino}-1H-benzimidazol-5-yl)piperazine-1-carboxylate (2.5 g, 4 mmol) in methanol (100 mL) was added 4 N hydrogen chloride in 1,4-dioxane (20 mL). The solution was stirred at room temperature for 48 hours. The resulting suspension was filtered to give 2.0 g of N4-(5-bromo-2-methylphenyl)-N5-(5-piperazin-1-yl-1H-benzimidazol-2-yl)-1H-imidazole-4,5-dicarboxamide hydrochloride. 1H-NMR (400 MHz, DMSO-d6) δ 12.62 (br s, 1H), 12.50 (br s, 1H), 11.20 (br s, 1H), 9.28 (d, 1H), 9.00 (d, 1H), 8.39 (s, 1H), 7.86 (s, 1H), 7.60 (d, 1H), 7.42 (d, 1H), 7.31 (d, 1H), 7.21 (s, 1H), 7.03 (d, 1H), 4.23 (br s 2H), 3.94 (m, 2H), 3.33 (m, 2H), 2.91 (m, 2H), 2.29 (s, 3H), 2.11 (m, 1H), 1.94 (m, 2H), 1.54 (m, 2H). MS (EI): 553 (MH+).

Provenance & Evidence