反应详情

A hydrogenation vessel was charged with 4-(3-(4-methylpiperazin-1-yl)propoxy)-2-nitroaniline (1.4 g, 4.76 mmol), ethanol (100 mL) and 10% palladium on charcoal (1 g). The reaction vessel was shaken on Parr hydrogenation apparatus. After 2 hours, the reaction mixture was filtered through a plug of Celite and washed with methanol. The resulting filtrate was concentrated under reduced pressure to 1.2 g of 4-(3-(4-methylpiperazin-1-yl)propoxy)benzene-1,2-diamine (95% yield), and was used without any further purification. MS (EI: 265 (MH+).

1. filtrationthe reaction mixture was filtered through a plug of Celite
2. washwashed with methanol