3-Aminosalicylic acid → HCID 66621027, compound

HRID 415139Notes

Reaction equation

HRID 415139 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[OH:11].Cl[C:13]([C:15]1([CH3:30])[CH2:19][CH2:18][CH2:17][N:16]1[C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])=O>>[CH2:23]([O:22][C:20]([N:16]1[CH2:17][CH2:18][CH2:19][C:15]1([C:30]1[O:11][C:3]2[C:4]([C:5]([OH:7])=[O:6])=[CH:8][CH:9]=[CH:10][C:2]=2[N:1]=1)[CH3:13])=[O:21])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 684433-Aminosalicylic acidHCID 86633083Benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate

Product 1

HCID 66621027HCID 66621027, compound

Procedure

2-(1-(Benzyloxycarbonyl)-2-methylpyrrolidin-2-yl)benzo[d]oxazole-7-carboxylic acid is prepared from 3-aminosalicylic acid and benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate using identical conditions described in Example 3A. MS (ESI) m/e 381 [M+H]+.

Sources & evidence

ORD record
ord-bf98d0fbcfdf4bd8a665bd82b016ba7d
Source dataset
uspto-grants-2012_01
Patent number
US08088760B2

Reaction notes

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