3-Aminosalicylic acid → 2-(Octahydro-1H-quinolizin-1-yl)benzo[d]oxazole-7-carboxamide

HRID 415140Notes

Reaction equation

HRID 415140 reaction equation
[CH2:1]1[CH:10]2[N:5]([CH2:6][CH2:7][CH2:8][CH2:9]2)[CH:4](C(Cl)=O)[CH2:3][CH2:2]1.NC1C=CC=C(C(O)=O)C=1O.C1C2N(CCCC2)C([C:35]2[O:36][C:37]3[C:43]([C:44]([NH2:46])=[O:45])=[CH:42][CH:41]=[CH:40][C:38]=3[N:39]=2)CC1>>[CH:9]1([C:35]2[O:36][C:37]3[C:43]([C:44]([NH2:46])=[O:45])=[CH:42][CH:41]=[CH:40][C:38]=3[N:39]=2)[CH:10]2[N:5]([CH2:4][CH2:3][CH2:2][CH2:1]2)[CH2:6][CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 684433-Aminosalicylic acidHCID 441811372-(octahydro-1H-quinolizin-4-yl)benzo[d]oxazole-7-carboxamideHCID 86633084octahydro-1H-quinolizine-4-carbonyl chloride

Product 1

HCID 441811352-(Octahydro-1H-quinolizin-1-yl)benzo[d]oxazole-7-carboxamide

Procedure

Following the experimental procedure as described in Examples 2A to 2B, and substituting benzyl 4-methylbenzoylchlordie with octahydro-1H-quinolizine-4-carbonyl chloride, and replacing 3-hydroxyanthranilic with 3-aminosalicylic acid, the title compound 2-(octahydro-1H-quinolizin-4-yl)benzo[d]oxazole-7-carboxamide is made

Sources & evidence

ORD record
ord-f67b3755072e4f15bf576d1dc26277da
Source dataset
uspto-grants-2012_01
Patent number
US08088760B2

Reaction notes

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