Thionyl Chloride → HCID 86633085, compound

HRID 415145Notes

Reaction equation

HRID 415145 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:19])=O>>[F:1][C:2]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:8]=[CH:7][C:3]=1[C:4]([Cl:19])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 63679065HCID 63679065, compound

Product 1

HCID 86633085HCID 86633085, compound

Conditions

Temperature
70 °C

Procedure

Thionyl chloride (20 ml) was added to 2-fluoro-4-(pyridine-2-yl)benzoic acid (1.91 g, 8.66 mmol) and the mixture was stirred at 70° C. overnight. The solvent was evaporated under reduced pressure and the residue was dried in vacuum to yield 2-fluoro-4-(pyridin-2-yl)benzoyl chloride.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was dried in vacuum

Sources & evidence

ORD record
ord-ece7a3a817864902a0e9c9e02344f51e
Source dataset
uspto-grants-2012_01
Patent number
US08088760B2

Reaction notes

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