p-Toluenesulfonic acid → HCID 66620966, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 3-(2-fluoro-4-(pyridin-2-yl)benzamido)-2-hydroxybenzoate (1.40 g, 3.8 mmol) and 4-methylbenzenesulfonic acid (1.82 g, 9.6 mmol) were added to toluene (50 mL) and the mixture was stirred at 118° C. for 2 days. The resulting mixture was extracted with ethyl acetate (100 mL×4) and concentrated. The crude product was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=20/1 to 10/1). 500 mg of methyl 2-(2-fluoro-4-(pyridin-2-yl)phenyl)benzo[d]oxazole-7-carboxylate was obtained as a solid; yield 38%. LC-MS (ESI) m/z: 349 (M+1)+.

Provenance & Evidence