Ammonia → HCID 66621105, compound

Participants

Reaction Steps

Methyl 2-(2-fluoro-4-(pyridin-2-yl)phenyl)benzo[d]oxazole-7-carboxylate (500 mg, 1.40 mmol) was added to ammonia in methanol (30 ml) and the mixture was stirred at room temperature for 3 days. The solid was filtered, washed with methanol and ammonium hydroxide, dried in vacuum. 400 mg of 2-(2-fluoro-4-(pyridin-2-yl)phenyl)benzo[d]oxazole-7-carboxamide as a solid was obtained, yield 84%. 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 7.5-7.54 (m, 2H), 7.87-8.04 (m, 5H), 8.21-8.23 (m, 3H), 8.47 (s, 1H), 8.76 (s, 1H); LC-MS (ESI) m/z: 334 (M+1)+.

Provenance & Evidence