Ammonia → HCID 66621564, compound

Participants

Reaction Steps

Methyl 2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)benzo[d]oxazole-7-carboxylate (200 mg, 1.40 mmol) was added to ammonia in methanol (10 mL) and the mixture was stirred at room temperature for 3 days. The mixture was concentrated, and then purified by prep-HPLC to obtain 2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)benzo[d]oxazole-7-carboxamide as a white solid (34.6 mg, yield 18%). 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 1.50-1.55 (m, 1H), 1.74-1.79 (m, 2H), 2.18-2.23 (m, 1H), 2.95-3.02 (m, 2H), 4.19-4.23 (m, 1H), 7.42-7.51 (m, 3H), 7.74-7.80 (br s, 1H), 7.80-7.82 (d, J=6.8 Hz, 2H), 7.96-7.98 (dd, J1=7.6 Hz, J2=0.8 Hz, 1H), 8.22 (t, J=8.4 Hz, 1H); LC-MS (ESI) m/z: 326 (M+1)+.

Provenance & Evidence