N,N-Dimethylglycine → HCID 66621408, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3-aminophenyl)benzo[d]oxazole-4-carboxamide (60 mg, 0.23 mmol) in DMF (3 mL) was added HOBT (35 mg, 0.26 mmol), dimethylglycine (24 mg, 0.23 mmol), DIPEA (91 mg, 0.7 mmol) and EDCI (54 mg, 0.29 mmol). The mixture was stirred at 30° C. for 18 hr. The reaction mixture was purified by pre-HPLC to obtain 2-(3-(2-(dimethylamino)acetamido)phenyl)benzo[d]oxazole-4-carboxamide (30 mg, yield 37%). 1H-NMR (400 MHz, DMSO-d6) δ 2.29 (s, 6H), 3.12 (s, 2H), 7.54-7.58 (m, 2H), 7.95-8.06 (m, 5H), 8.46 (s, 1H), 8.69 (s, 1H), 10.11 (s, 1H); LC-MS (ESI) m/z 339 [M+1]−.

Provenance & Evidence