HCID 18354634, compound → HCID 66621373, compound

Participants

Reaction Steps

To a mixture of 2-(4-nitrophenyl)benzo[d]oxazole-4-carboxamide (800 mg, 2.83 mmol) in methanol (30 mL) was added Raney Ni (2 g), the mixture was purged into hydrogen and stirred at room temperature for 5 hr. The mixture was filtered, washed with methanol, the filtrate was evaporated under reduced pressure to obtain a solid, purified by silica gel chromatography to give 2-(4-aminophenyl)benzo[d]oxazole-4-carboxamide as a yellow solid (450 mg, yield 63%). 1H-NMR (400 MHz, DMSO-d6) δ 6.16 (s, 2H), 6.69-6.72 (d, J=9.2 Hz, 2H), 7.38-7.42 (t, J=8 Hz, 1H), 7.85-7.96 (m, 5H), 8.54 (s, 1H); LC-MS (ESI) m/z 254 [M+1]+.

Provenance & Evidence