反应详情

Methyl 5-fluoro-2-(4-((methylamino)methyl)phenyl)benzo[d]oxazole-7-carboxylate (25 mg, 0.06 mmol) in ammonium water (2 mL) was stirred at 30° C. for 17 hr and the solvents were evaporated; the residue was purified by pre-HPLC to obtain 5-fluoro-2-(4-((methylamino)methyl)phenyl)benzo[d]oxazole-7-carboxamide as a white solid (4 mg, yield 22%). 1H-NMR (400 MHz, MeOD-d4) δ 2.07 (s, 1H), 2.41 (s, 3H), 3.85 (s, 2H), 7.52-7.55 (m, 2H), 7.57-7.61 (m, 2H), 8.25-8.27 (d, J=7.6 Hz, 2H); LC-MS (ESI) m/z 300 [M+1]+.

1. customthe solvents were evaporated
2. customthe residue was purified by pre-HPLC