Azanium;hydrate → HCID 66620892, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(3-(piperazin-1-ylmethyl)phenyl)benzo[d]oxazole-7-carboxylate (79 mg, 0.23 mmol) and ammonium water (64.4 mg, 1.84 mmol) were added to ethanol (30 mL) and the mixture was stirred at 30° C. for 1 hr. The resulting mixture was evaporated under reduced pressure and purified with Pre-HPLC to obtain 2-(3-(piperazin-1-ylmethyl)phenyl)benzo[d]oxazole-7-carboxamide (12 mg, yield 13%). 1H-NMR (400 MHz, DMSO-d6) δ 2.91 (s, 4H), 3.21 (s, 4H), 4.20 (s, 2H), 7.48-7.52 (t, J=8 Hz, 1H), 7.67 (s, 2H), 7.81-7.97 (m, 4H), 8.31 (s, 2H); LC-MS (ESI) m/z 337 [M+1]+.

Provenance & Evidence