p-Toluenesulfonic acid → HCID 66621160, compound

Participants

Reaction Steps

Methyl 2-hydroxy-3-(nicotinamido)benzoate (215 mg, 0.79 mmol) and 4-methylbenzenesulfonic acid (400 mg, 2.0 mmol) were added to toluene (10 mL) and the mixture was stirred at reflux for 10 hr. The resulting mixture was extracted with ethyl acetate (100 mL×4) and concentrated to obtain methyl 2-(pyridin-3-yl)benzo[d]oxazole-7-carboxylate as a solid (135 mg, yield 67%); LC-MS (ESI) m/z 255 [M+1]+.

Provenance & Evidence