Azanium;hydrate → HCID 66620926, compound

Participants

Reaction Steps

Methyl 2-(pyridin-3-yl)benzo[d]oxazole-7-carboxylate (135 mg, 0.53 mmol) in ammonium water (15 mL) was stirred at 25° C. overnight. The solvent was removed under reduced pressure. The crude product was purified by pre-HPLC to obtain 2-(pyridin-3-yl)benzo[d]oxazole-7-carboxamide a solid (39 mg, yield 31%). 1H-NMR (400 MHz, DMSO-d6) δ 7.50-7.54 (t, J=8 Hz, 1H), 7.65-7.69 (q, 1H), 7.65-7.69 (q, 1H), 7.85-7.87 (d, J=8 Hz, 1H), 7.91-7.93 (d, J=8 Hz, 2H), 7.99-8.01 (d, J=8 Hz, 1H), 8.64-8.66 (d, J=8 Hz, 1H), 8.81-8.82 (d, J=4 Hz, 1H), 9.46-9.47 (s, J=4 Hz, 1H); LC-MS (ESI) m/z 240 [M+1]+.

Provenance & Evidence