N,O-Dimethylhydroxylamine → HCID 86633092, compound

HRID 415243Notes

Reaction equation

HRID 415243 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:5][CH:4]=1.[CH3:22][O:23][NH:24][CH3:25]>>[CH3:22][O:23][N:24]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:5][CH:4]=1)[CH3:25]

Participants

3

Reactant 2

HCID 14232N,O-DimethylhydroxylamineHCID 66621208Methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-7-carboxylate

Product 1

HCID 86633092HCID 86633092, compoundYield 65%

Procedure

Following the experimental procedure as described in Example 144 C, and replacing methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-4-carboxylate with methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-7-carboxylate and substituting dimethylamine with methoxy(methyl)amine, methyl 2-(4-((methoxy(methyl)amino)methyl)phenyl)benzo[d]oxazole-7-carboxylate (Yield: 65%. LC-MS (ESI) m/z: 327 (M+1)+) was made.

Sources & evidence

ORD record
ord-3ea3f1436bba43ac92f8ffd7766b2166
Source dataset
uspto-grants-2012_01
Patent number
US08088760B2

Reaction notes

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