O-Methylhydroxylamine → HCID 86633093, compound

HRID 415244Notes

Reaction equation

HRID 415244 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][C:15]([F:22])=[CH:14][C:12]=3[N:13]=2)=[CH:5][CH:4]=1.[CH3:23][O:24][NH2:25]>>[F:22][C:15]1[CH:16]=[C:17]([C:18]([O:20][CH3:21])=[O:19])[C:11]2[O:10][C:9]([C:6]3[CH:7]=[CH:8][C:3]([CH2:2][NH:25][O:24][CH3:23])=[CH:4][CH:5]=3)=[N:13][C:12]=2[CH:14]=1

Participants

3

Reactant 2

HCID 4113O-MethylhydroxylamineHCID 66621057Methyl 2-(4-(bromomethyl)phenyl)-5-fluorobenzo[d]oxazole-7-carboxylate

Product 1

HCID 86633093HCID 86633093, compoundYield 87%

Procedure

Following the experimental procedure as described in Example 144 C, and replacing methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-4-carboxylate with methyl 2-(4-(bromomethyl)phenyl)-5-fluorobenzo[d]oxazole-7-carboxylate and substituting dimethylamine with methoxyamine, methyl 5-fluoro-2-(4-((methoxyamino)methyl)phenyl)benzo[d]oxazole-7-carboxylate (Yield: 87%. LC-MS (ESI) m/z: 331 (M+1)+) was made.

Sources & evidence

ORD record
ord-0446a51b5ba14df9a319d3d886a1f683
Source dataset
uspto-grants-2012_01
Patent number
US08088760B2

Reaction notes

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