N,O-Dimethylhydroxylamine → HCID 86633094, compound

HRID 415245Notes

Reaction equation

HRID 415245 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][C:15]([F:22])=[CH:14][C:12]=3[N:13]=2)=[CH:5][CH:4]=1.[CH3:23][O:24][NH:25][CH3:26]>>[F:22][C:15]1[CH:16]=[C:17]([C:18]([O:20][CH3:21])=[O:19])[C:11]2[O:10][C:9]([C:6]3[CH:7]=[CH:8][C:3]([CH2:2][N:25]([O:24][CH3:23])[CH3:26])=[CH:4][CH:5]=3)=[N:13][C:12]=2[CH:14]=1

Participants

3

Reactant 2

HCID 14232N,O-DimethylhydroxylamineHCID 66621057Methyl 2-(4-(bromomethyl)phenyl)-5-fluorobenzo[d]oxazole-7-carboxylate

Product 1

HCID 86633094HCID 86633094, compoundYield 84%

Procedure

Following the experimental procedure as described in Example 144 C, and replacing methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-4-carboxylate with methyl 2-(4-(bromomethyl)phenyl)-5-fluorobenzo[d]oxazole-7-carboxylate and substituting dimethylamine with methoxy(methyl)amine, methyl 5-fluoro-2-(4-((methoxy(methyl)amino)methyl)phenyl)benzo[d]oxazole-7-carboxylate (Yield: 84%. LC-MS (ESI) m/z: 345 (M+1)+) was made.

Sources & evidence

ORD record
ord-ebb4616ef114469880caa3e1c68e846b
Source dataset
uspto-grants-2012_01
Patent number
US08088760B2

Reaction notes

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