HCID 66621374, compound → HCID 66620732, compound

Participants

Reaction Steps

A mixture of benzyl 4-(7-carbamoylbenzo[d]oxazol-2-yl)piperidine-1-carboxylate (98 mg, 0.26 mmol), 10% Pd/C (20 mg) in methanol (30 ml) was stirred at room temperature over 1 atm hydrogen for 2 hr. The mixture was filtered, and evaporated under reduced pressure. The residue was purified by pre-HPLC. 21 mg of 2-(piperidin-4-yl)benzo[d]oxazole-7-carboxamide as a solid was obtained, yield 33%. LCMS (ESI) m/z: 246 (M+1)+. 1H-NMR (400 MHz, DMSO-d6): δ 1.24 (brs, 1H), 1.71-1.74 (m, 2H), 2.03-2.06 (d, J=12 Hz, 2H), 2.64 (t, 2H), 3.01-3.04 (t, 2H), 3.14 (t, 1H), 7.41 (t, J=7.2 Hz, 1H), 7.72 (d, J=7.2 Hz, 1H), 7.72 (brs, 1H), 7.78 (brs, 1H), 7.85 (d, J=7.2 Hz, 1H).

Provenance & Evidence