HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415260Generated: October 30, 2026
Azane;hydrate → Benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)azetidine-1-carboxylate
https://huagongshe.com/reaction/415260
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Azane;hydrate | HCID 12896473 | — |
| Reactant | Methyl 2-(1-(benzyloxycarbonyl)azetidin-3-yl)benzo[d]oxazole-7-carboxylate | HCID 66621079 | — |
| Product | Benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)azetidine-1-carboxylate | HCID 66621201 | 60% |
Reaction Steps
Methyl 2-(1-(benzyloxycarbonyl)azetidin-3-yl)benzo[d]oxazole-7-carboxylate (280 mg, 0.76 mmol) was added to ammonia water (10 ml) and the mixture was stirred at 35° C. for overnight. Then the solid was filtered. 160 mg of benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)azetidine-1-carboxylate was obtained, yield 60%. LC-MS (ESI) m/z: 352 (M+1)+. (M+1)+,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088760B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-e6454250e1ee489089c1a04f08d020eb |
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| Source note | uspto-grants-2012_01 |
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