反应详情

A mixture of benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)azetidine-1-carboxylate (160 mg, 0.45 mmol), 10% Pd/C (20 mg) of methanol (30 ml) was stirred at room temperature for 2 h. Then the mixture was filtered and evaporated under reduced pressure. The residue was purified by pre-HPLC. 6 mg of 2-(azetidin-3-yl)benzo[d]oxazole-7-carboxamide was obtained. LC-MS (ESI) m/z: 218 (M+1)+. 1H-NMR (400 MHz, CDCl3): δ 1.84 (brs, 1H), 3.39 (t, 3H), 4.11 (t, 3H), 4.21 (m, 1H), 6.12 (brs, 1H), 6.96 (brs, 1H), 7.39 (t, J=8 Hz, 1H), 7.81 (d, J=8 Hz, 1H), 8.01 (d, J=8 Hz, 1H).

1. filtrationThen the mixture was filtered
2. customevaporated under reduced pressure
3. customThe residue was purified by pre-HPLC