Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid | HCID 234339 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate | HCID 2776575 | — |
반응 단계
To a stirred solution of 1-(benzyloxycarbonyl)piperidine-3-carboxylic acid (1.05 g, 4 mmol) in anhydrous dichloromethane (10 mL), thionyl chloride (0.573 g, 4.81 mmol) was added drop wise at 0° C. After the addition, the solution was stirred at room temperature overnight. Solvent was removed in vacuum to give benzyl-3-(chlorocarbonyl)piperidine-1-carboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088760B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-a320e3ceef724816a88a4b0fb3ddc041 |
| 출처 메모 | uspto-grants-2012_01 |