反应详情

To a stirred solution of 1-(benzyloxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid (1.0 g, 3.8 mmol) in anhydrous dichloromethane (10 mL) thionyl chloride (0.54 g, 4.56 mmol) was added drop wise at 0° C. After the addition, the solution was stirred at room temperature overnight. Solvent was removed in vacuum to give benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate.

1. additionAfter the addition
2. customSolvent was removed in vacuum