Ammonia → HCID 46847387, compound

Participants

Reaction Steps

Methyl 2-(4-(pyridin-4-yl)phenyl)benzo[d]oxazole-7-carboxylate (160 mg, 0.5 mmol) was added to ammonia in methanol (30 mL) and the mixture was stirred at room temperature for 3 days. Then the solid was filtered, washed with methanol, dried in vacuum. 140 mg of solid of 2-(4-(pyridin-4-yl)phenyl)benzo[d]oxazole-7-carboxamide was obtained, yield: 90%. 1H-NMR (400 MHz, DMSO-d6) δ 7.50-7.54 (t, J=8 Hz, 1H), 7.83-7.86 (m, 2H), 7.89-7.96 (brs, 2H), 7.99-8.01 (d, J=7.6 Hz, 2H), 8.08-8.10 (d, J=8.4 Hz, 2H); 8.44-8.46 (d, J=8.4 Hz, 2H); 8.71-8.72 (d, J=4.4 Hz, 2H); LC-MS (ESI) m/z: 316 (M+1)+.

Provenance & Evidence