Ammonia → Benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)piperidine-1-carboxylate

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Reaction Steps

Methyl 2-(1-(benzyloxycarbonyl)piperidin-3-yl)benzo[d]oxazole-7-carboxylate (360 mg, 0.92 mmol) was added to a solution of ammonia in methanol (10 mL) and the mixture was stirred at room temperature overnight. Then the mixture was evaporated under reduced pressure and extracted with ethyl acetate (100 mL×4), the organic phase was dried with anhydrous sodium sulfate and evaporated under reduced pressure. 200 mg benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)piperidine-1-carboxylate was obtained. Yield: 26%. LC-MS (ESI) m/z: 380 (M+1)+.

Provenance & Evidence