反应详情

A mixture of benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)piperidine-1-carboxylate (200 mg, 0.27 mmol), 10% Pd/C (40 mg) in methanol (30 ml) was stirred at room temperature over 1 atm hydrogen for 2 hr. Then the mixture was filtered and evaporated, 160 mg of 2-(piperidin-3-yl)benzo[d]oxazole-7-carboxamide as a solid was obtained. Yield 24%. LC-MS (ESI) m/z: 246 (M+1)+.

1. filtrationThen the mixture was filtered
2. customevaporated