HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → (S)-4-(2-methyloxy-3-(1-methyloxyheptyl)phenyl)thiazole-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | (S)-2-chloro-1-(2-methyloxy-3-(1-methyloxyheptyl)phenyl)ethanone | HCID 59544890 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-4-(2-methyloxy-3-(1-methyloxyheptyl)phenyl)thiazole-2-amine | HCID 59544880 | 32% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
(S)-2-chloro-1-(2-methyloxy-3-(1-methyloxyheptyl)phenyl)ethanone (11) obtained in the third step was dissolved in ethanol (30 mL), thiourea (1.4 g) was added, and the mixture was stirred at 100° C. for 3 hours. Extraction with toluene and purification by silica gel chromatography afforded (S)-4-(2-methyloxy-3-(1-methyloxyheptyl)phenyl)thiazole-2-amine (12, 4.22 g, yield 32%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530668B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-7bc47f66264e4ddb87abfa4879dd0aca |
| Source note | uspto-grants-2013_09 |