Ammonium → HCID 44179987, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(3-(4-isobutyrylpiperazine-1-carbonyl)phenyl)benzo[d]oxazole-7-carboxylate (150 mg, 0.34 mmol) was added to ammonium in methanol (10 mL) in a sealing tube and stirred at 25° C. for 3 days. The solvent was removed under reduced pressure. The crude product was purified by pre-HPLC to obtain 2-(3-(4-isobutyrylpiperazine-1-carbonyl)phenyl)benzo[d]oxazole-7-carboxamide as a white solid (20 mg, yield 14%). 1H-NMR (400 MHz, CD3OD) δ: 1.12-1.13 (d, J=6 Hz, 6H), 2.97 (brs, 1H), 3.55-3.85 (m, 8H), 7.50-7.54 (t, J=8.0 Hz, 1H), 7.71-7.75 (m, 2H), 7.91-7.95 (m, 2H), 8.41-8.45 (m, 2H); LC-MS (ESI) m/z: 421 (M+1)+.

Provenance & Evidence