p-Toluenesulfonic acid monohydrate → HCID 66621372, compound

Participants

Reaction Steps

Methyl 3-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)benzamido)-2-hydroxybenzoate (160 mg, 0.35 mmol) and 4-methylbenzenesulfonic acid monohydrate (200 mg, 1 mmol) were added to toluene (10 mL) and the mixture was stirred at reflux for 16 hr. The resulting mixture was extracted with ethyl acetate (100 mL×4) and concentrated to yield methyl 2-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)phenyl)benzo[d]oxazole-7-carboxylate as a solid (130 mg, yield: 85%). LC-MS (ESI) m/z: 434 (M+1)+.

Provenance & Evidence