Ammonium → HCID 44181680, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)phenyl)benzo[d]oxazole-7-carboxylate (130 mg, 0.33 mmol) was added to ammonium in methanol (10 mL) in a sealing tube and stirred at 25° C. for 3 days. The solvent was removed under reduced pressure. The crude product was purified by pre-HPLC to obtain 2-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)phenyl)benzo[d]oxazole-7-carboxamide (30 mg, yield 22%). 1H-NMR (400 MHz, CD3OD) δ: 0.85-0.92 (m, 4H), 1.29 (m, 1H), 3.20-3.99 (m, 8H), 7.52-7.56 (t, J=8.0 Hz, 1H), 7.74-7.75 (m, 2H), 7.92-7.97 (m, 2H), 8.43-8.47 (m, 2H); LC-MS (ESI) m/z: 419 (M+1)+.

Provenance & Evidence